Trent Stubbs

Chemistry Research Technician Adjunct Professor of Chemistry

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Trent Stubbs is an Adjunct Professor of Chemistry and a Furman University alumn whose research integrates prebiotic chemistry, chemical biology, and translational innovation. He earned his B.S. in Chemistry from Furman University, where he was named a Furman Fellow during his senior year, inducted into Quaternion (Furman’s honor society), and was awarded the American Institute of Chemists Award in Chemistry for academic achievement and professional promise.

As an undergraduate researcher at Furman, Trent published a first-author paper in Nature Chemistry describing an enzyme-free, α-keto acid–based proto-metabolic network analogous to the modern citric acid cycle. He went on to earn his M.S. in Chemistry from Emory University, where his work in the Heemstra lab resulted in a co-first-author publication in Journal of the American Chemical Society (JACS) on glyoxylated nucleoside reverse transcriptase inhibitors (NRTIs) as a novel prodrug motif for improving drug pharmacokinetic limitations.
Trent is also the co-founder of Aconabolics, LLC, a chemical manufacturing startup producing isotopically labeled metabolites for medical diagnostic research. He is a named inventor on a U.S. patent and has led the translation of lab-developed chemistry into internationally distributed research products.

Education

  • M.S., Emory University
  • B.S., Furman University

Publications

  • Ter Ovanessian, L. M. P.; Ryan, K. L.; Shaarda, J.; Stubbs, R. T.; Krishnamurthy, R.; Springsteen, G. Angew. Chem. Int. Ed., 64, 19 (2025)
  • Diane B. Karloff, R. Trent Stubbs, Olamilekan J. Ibukun, Steve D. Knutson, Scott H. James, Jennifer Heemstra. J. Am. Chem. Soc. 146, 43, 29402–29406 (2024)
  • Stubbs, R. T.; Mahipal Y.; Krishnamurthy, R.; Springsteen, G. An Analog of the Reductive Citric Acid Cycle Comprised Entirely of a-Ketoacids, Nature Chemistry 12, 1016–1022 (2020)

Patents

  • Stubbs, R. T.; Springsteen, G. Synthesis of organic acids from alpha-keto-acids, patent granted, US11505519B2.

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