Assistant Professor of Biology
Dr. Chandrasekaran grew up in Kerala and pursued her undergraduate degree in Microbiology in Mumbai and a Masters degree in Biotechnology in Baroda. She attended Louisiana State University for her Ph.D. studies in Biochemistry, where she was trained as a yeast biologist, understanding biochemical pathways involved in nutrient stress response in yeast. She researched genotoxic and osmotic stress response mechanisms and their effects on DNA Replication in human cell lines at University of North Carolina, Chapel Hill for her postdoctoral training. She was a Visiting Assistant Professor at Elon University, North Carolina, where she worked on osmotic stress response in zebra fish. She went on to serve as a lecturer at Clemson University where she studied heat stress response mechanisms in fungi and their effects on cytokinesis. Dr.Chandrasekaran joined the Biology faculty at Furman University in Fall 2017, where she works on drug resistance in fungi.
Dr.Chandrasekaran works on stress response mechanisms in the fungal pathogen, Cryptococcus neoformans. Specifically her lab is interested in understanding how drug resistance develops among fungi and how the ability to resist anti-fungal drugs is related to the ability of fungi to tolerate heat, osmotic, and oxidative stress in the host cells. She studies pathways that integrate drug resistance with stress response mechanisms. Using the power of yeast genetics her lab identifies candidate proteins that interact with known proteins that get upregulated during stress. Her lab also explores how cell division mechanisms are altered in yeast in response to stress.
- Ph.D.,Biochemistry, Louisiana State University
- MSc., Biotechnology, Maharaja Sayajirao University
- BSc, Microbiology, University of Mumbai
- Dbouk NH*, Covington MB*, Nguyen K*, Chandrasekaran S. Increase of reactive oxygen species contributes to growth inhibition by fluconazole in Cryptococcus neoformans. BMC Microbiol. 2019 Nov 6;19(1):243. doi: 10.1186/s12866-019-1606-4.
- “No matter if you are black or while: A study on genetic variations in skin color” by Srikripa Chandrasekaran and Linda Niedziela; National Center for Case Study Collection, at University of Buffalo, March 2018
- Altamirano S, Chandrasekaran S, and Kozubowski L., Mechanisms of cytokinesis in basidiomycetous yeasts. Fungal Biology Reviews (January, 2017)
- Varma D, Chandrasekaran S, Salmon E, and Cook J G., Recruitment of the human Cdt1 protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. 2012 May 13;14(6):593-603
- Chandrasekaran S, Tan T X, Hall J R, and Cook J G., Stress-activated MAP kinases, p38 and JNK, control the stability and activity of the Cdt1 DNA replication licensing factor. Mol Cell Biol. 2011 Nov;31(22):4405-16
- Chandrasekaran S, Reidy K T, and Cook J G,.Regulation of DNA replication origin licensing during genotoxic and cellular stress Biochemistry, Genetics and Molecular Biology "Fundamental Aspects of DNA Replication", book edited by Jelena Kušić-Tišma. 2011 September Open access website: www.intechopen.com/books/fundamental-aspects-of-dna-replication
- Chandrasekaran S, Skowyra D., The emerging regulatory potential of SCFMet30-mediated polyubiquitination and proteolysis of the Met4 transcriptional activator. Cell Div., 2008 Jul 25:3-11