Meghan Breen

Meghan Breen

Assistant Professor, Chemistry

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Meghan Breen earned a B.S. in chemistry from Eastern Illinois University in 2008 and a Ph.D. in medicinal chemistry from the University of Michigan in 2014. During her graduate work under the guidance of Prof. Matthew Soellner she developed screening methods to identify ATP-noncompetitive kinase inhibitors. After earning her Ph.D. she stayed at the University to Michigan to complete postdoctoral studies in chemical biology under the guidance of Prof. Anna Mapp. Her postdoctoral research focused on developing chemical tools with applications in chemical and synthetic biology, particularly for the study of transient protein-protein interactions. During her postdoctoral studies, Dr. Breen was named a Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation, and she also taught courses in the Department of Chemistry and Program in Chemical Biology.

Dr. Breen joined the faculty at Furman University in Fall 2019. Her research program dissects molecular mechanisms that regulate drug resistance in pathogenic fungi.

Honors

  • Howard Hughes Medical Institute Fellow of the Life Sciences Research Foundation (2016-2019)
  • Outstanding Postdoctoral Fellow Award, University of Michigan (2016)
  • American Foundation for Pharmaceutical Education Pre-Doctoral Fellowship (2012-2014)
  • National Institutes of Health Pharmacological Sciences Training Grant (2009-2011)
  • Presidential Scholarship, Eastern Illinois University (2004-2008)

Education

  • Postdoctoral Fellowship, Chemical Biology, University of Michigan
  • Ph.D. Medicinal Chemistry, University of Michigan
  • B.S. Chemistry, Eastern Illinois University

Publications

  • Joiner, C.M.*; Breen, M.E.*; Mapp, A.K. Electron‐deficient p‐benzoyl‐L‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions. Protein Science, 2019, 28, 1163-1170. (*authors contributed equally)
  • Breen, M.E.; Mapp, A.K. Modulating the masters: chemical tools to dissect CBP and p300
    function. Current Opinion in Chemical Biology, 2018, 45, 195-203.
  • Kersten, K.M.; Breen, M.E.; Mapp, A.K.; Matzger, A.J. Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide. Chemical Communications, 2018, 54, 9286-9289.
  • Joiner, C.M.*; Breen, M.E.*, Clayton, J.; Mapp, A.K. A Bifunctional Amino Acid Enables Both
    Covalent Chemical Capture and Isolation of In Vivo Protein-Protein Interactions. ChemBioChem, 2017, 18, 181-184. (*authors contributed equally)
  • Brandvold, K.R.; Santos, S.M.; Breen, M.E.; Lachacz, E.J.; Steffey, M.E.; Soellner, M.B. Exquisitely Specific Bisubstrate Inhibitors of c-Src Kinase. ACS Chemical Biology, 2015, 10, 1387-1391.
  • Breen, M.E.; Soellner, M.B. Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges. ACS Chemical Biology, 2015, 10, 175-189.
  • Breen, M.E.; Steffey, M.E.; Lachacz, E.J.; Kwarcinski, F.E.; Fox, C.C.; Soellner, M.B. Substrate
    Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src
    Inhibitors. Angewandte Chemie International Edition 2014, 53, 7010-7013.
  • Yestrepsky, B.D.; Xu, Y.; Breen, M.E.; Li, X.; Rajeswarana, W.G.; Ryu, J.G.; Sorenson, R.J.; Tsume, Y.; Wilson, M.W.; Zhang, W.; Sun, D.; Sun, H.; Larsen, S.D. Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression. Bioorganic & Medicinal Chemistry, 2013, 21, 1880-1897.
  • Grove, R.C.; Malehorn, S.H.; Breen, M.E.; Wheeler, K.A. A photoreactive crystalline quasiracemate. Chemical Communications, 2010, 46, 7322-7324.
  • Talukdar, A.; Breen, M.; Bacher, A.; Illarionov, B.; Fischer, M.; Georg, G.; Ye, Q.-Z.; Cushman, M. Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity. Journal of Organic Chemistry, 2009, 74, 5123-5134.
  • Breen, M.E.; Tameze, S.L.; Dougherty, W.G.; Kassel, W.S.; Wheeler, K.A. Structural Studies of Enantiomers, Racemates, and Quasiracemates. 2-(3-Bromophenoxy)propionic Acid and 2-(3-Methoxyphenoxy)propionic Acid. Crystal Growth & Design, 2008, 8, 3863-3870.

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