As adults, anamniotic vertebrates (fish and amphibians) maintain a tremendous capacity to regenerate their central nervous systems. Our lab is interested in the molecular mechanisms that govern this ability; an ability which is severely limited in mammals. Further, because many of the cellular and molecular mechanisms involved in post-embryonic neurogenesis are similar to those in embryonic nervous system development, our lab is also interested in early brain development. Our lab is focused on genes that code for proteins with known roles in synapse development, stem cell proliferation, and the facilitation of axonal outgrowth. Specifically, our lab is investigating the roles of the small molecule GTPase, Rem2, and the membrane-associated lipid phosphate phosphatase, Prg-1, in brain repair and development. We use the rainbow trout and the bullfrog as model systems in the hope of gaining insight into the discrepancies between vertebrates with regard to adult neurogenesis.